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pentobarbital will lessen the level or influence of parecoxib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.Contraindicated (one)pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can decrease panobinostat levels